Endocrine Abstracts

Background: Patients with neuroendocrine tumours (NETs) and acromegaly are commonly treated with somatostatin analogs (SSAs), such as octreotide and lanreotide depot formulations. The Pharmathen syringe is now available in several European countries and the USA for lanreotide depot injection. When using SSAs, confidence in and ease of use with syringes are important for decision-making in long-term therapy. The aim of the PRESTO 3 study was to compare nurses’ preference f...

Background: Serum soluble alpha klotho (sαKL) is a circulating protein which had been shown to be very high in active acromegaly, and significantly reduced after disease control. Therefore, sαKL has been suggested as a new biomarker for growth hormone (GH) excess. In this study, we aimed to evaluate the impact of short-term stimulation and suppression of GH and acute modulation of glucose metabolism on sαKL concentrations.Methods: Serum s&...

Introduction: Medullary thyroid cancer (MTC) is a rare tumour. Mostly sporadic, 25% are associated with multiple endocrine neoplasia (MEN2A/B) or isolated familial MTC. Surgery is the only curative option: its response is defined as complete (no evidence of biochemical or structural disease), incomplete (only structural response) and persistence of structural disease. We aimed to analyse the clinical and pathological factors associated with the prognosis of MTC.<p class="a...

Introduction: The interaction between obesity and bone metabolism is complex and not fully understood. Historically, higher body weight was considered to be protective against osteoporosis. This association has affected clinical practice: body mass index (BMI) is one of the variables included in Fracture Risk Assessment Tool (FRAX), where a higher BMI leads to a lower fracture risk. Despite this association between bone mineral density (BMD) and body weight, it is not clear wh...

Introduction: Giant prolactinomas (diameter >4 cm) account for less than 5% of all prolactinomas and are usually associated with markedly elevated prolactin (PRL) levels. Despite their benign nature, these tumors can be invasive, potentially leading to mass effect symptoms in affected patients.Case Report: We report a case of a 40-year-old male admitted to the emergency department with a one-week history of headaches, right palpebral edema, and ptosi...

Background: Acromegaly is a rare disorder associated with excessive levels of growth hormone(GH) and insulin-like growth factor-1(IGF-1). GH/IGF-1 excess leads to morphologic craniofacial and acral changes as well as cardiometabolic complications, but the phenotypic changes and presentation differ across species.Aim: To present the resemblances and distinctive features of acromegaly in humans, cats and dogs.Methods: A literature re...

Introduction: Cancer treatment including oophorectomy, radiotherapy and chemotherapy with gonadotoxic agents may induce premature ovarian failure. Early diagnosis and treatment of ovarian failure avoids cardiovascular disorders, osteoporosis and compromised sexual health due to estrogen deficiency and also ensures growth and pubertal development in children.Aim: Raise awareness for early assessment and management of premature ovarian failure after cancer...

Introduction: Thyroid storm, a life-threatening manifestation of hyperthyroidism, presents a complex clinical challenge that demands swift and precise intervention. The heart is one of the most important target organs affected by the thyrotoxic state. Thyrotoxicosis may lead to sinus tachycardia, hypertension, tachycardiomyopathy, atrial fibrillation and heart failure.Case Presentation: A 46-year-old female presented to the emergency department with symp...

Introduction: Medullary thyroid carcinoma (MTC) arises from thyroid parafollicular C cells and accounts for <5% of thyroid cancers. Nearly 25% occur in the context of multiple endocrine neoplasia type 2 syndrome (MEN2) or familial isolated MTC.Objectives: Evaluation of clinical characteristics and evolution of patients with MTC.Methods: Retrospective analysis of clinical records of patients with MTC diagnosed from 2001 to 2023....

Introduction: Primary aldosteronism (PA) is a rare but underestimated cause of hypertension. PA has been associated with increased risk of malignancy through mechanisms involving up-regulation of the renin angiotensin system (RAS) promoting an enzymatic cascade influencing carcinogenesis. Recently, Microwave Ablation (MWA) has been established as an effective and safe minimal invasive treatment for Conn’s Disease.Aim: The authors present four clinic...